Abstract: Characteristic clinical and pathological findings in fifteen autopsy cases,13 males and 2 females,of cardiac rupture following acute myocardial infarction were reported. Its incidence is 30.6% of all autopsy cases of myocardial infarction treated in our hospital.The patients’ age ranged from 45 to 76 years,ten of them being over 60 years.Clinically,these patients had a history of protracted chest pain and/or vomitings,or“stress episode”,prior to the cardiac rupture.Most patients showed hypertension.Delay in the diagnosis of myocardial infarction,failure to put the patient to bedrest after the onset of sustained chest pain,were the frequent problems.When the cardiac rupture occurred,the ECG generally showed persisted electrical activity while the heart sounds（mechanical activity）disappeared（electro-mechanical dissociation）.The ECG in most of them showed sinus rhythm which gradually slowed down,and were followed by an A-V junctional escape rhythm with an intraventricular conduction defect（or idioventricular rhythm）with S-T change.The effective management of cardiac rupture consists of early diagnosis,control of vomiting and chest pain, prevention or therapy of hypertension or hypotcnsion and keeping the patient in bed for the first two weeks.