Abstract: Objective To observe the effect of different homogenated diets on blood biochemistry and hemoglobin in elderly type 2 diabetic patients with tube feeding. Methods Fifty-six type 2 diabetic patients were divided into home-made homogenated diet group,Sanjiu homogenated diet group and TPF-D group.Parameters of body height,body weight,waist circumference and hip circumference,as well as findings of biochemical testing including hemoglobin（Hb） of the patients were analyzed. Results The serum levels of uric acid（sUA）,iron（Fe）,calcium（Ca） and Hb were significantly higher in those after feeding the diets than in those before feeding the diets（P＜0.05）.The blood sodium（Na） level was higher while the blood potassium（K） level was lower in home-made homogenated diet group than in the other two groups（P＜0.05）.The sUA level was significantly higher in TPF-D group than in the other groups（P＜0.05）.The ApoA1 level was significantly higher in Sanjiu homogenated diet group than in the other groups（P＜0.05）.The blood Na level was higher and the blood K level was lower in home-made homogenated diet group than in the other groups（P＜0.05）.No significant difference was found in other parameters among the 3 groups. Conclusion The three homogenated diets can meet the nutrition requirements of elderly diabetic patients with tube feeding.Rational addition of nutrients according to the different conditions of such patients should be stressed if these diets are used for a long time due to their different advantages and disadvantages.