Abstract: Objective: To explore the appropriate conditions of polymerization for microwave energy to cure denture base resin.Methods: 120 specimens were treated by four methods: 3 microwave radiation heating treatments（MH₁: 162 W,for 12 min short times intermittent microwave cycle.MH₂: 162 W with 12 min consistent microwave cycle.MH₃: 900 W with 3 min consistent microwave cycle）.1 conventional heating treatment CH: keeping on temperature（74±1）℃ held for 12 h,water bath.After being polymerized,the specimens in each group were divided into test group MH₁、MH₂、MH₃ and CH to measure the flexural strength、flexural modulus、impact strength and Rockwell hardness.Results: Four sets of data analysis result indicated that microwave processing with the different condition of polymerization can get the different mechanical properties of the polymer（P＜0.05）.Conclusion: Within the limitations of this in vitro study,the better ideal polymerization processing technique is to use a low energy,short time,intermittent microwave cycle.