Abstract: Objective: To explore effective treatment of pulmonary infection in patients of severe burn with inhalation injury and burn-blast combined injury. Methods: The clinical data of pulmonary infection in six patients with severe burn with inhalation injury and burn-blast combined injury were summarized. Results: Pulmonary infection of six patients occurred in 3.5-6 days after burned.There were 5 cases accepted incision of trachea and depended on mechanical ventilation,and 3 cases among these suffered pulmonary infection after 2.5 days.All cases of pulmonary infection were cured by combined therapy. Conclusion: To early apply antibiotics,prevent and cure ventilator associated pneumonia,apply bronchofibroscope,strengthen the management air tube and nutritional support,and to positively treatment the raw surface of burn were effective treatments of pulmonary infection in patients of severe burn with inhalation injury.