LRP16基因在乳腺癌中的表达及临床意义

臧丽; 母义明; 韩为东; 赵亚力; 巴建明

LRP16基因在乳腺癌中的表达及临床意义

Expression of LRP16 gene in breast carcinoma and its clinical significance

摘要

摘要: 目的: 检测LRP16基因在乳腺癌中的表达及与乳腺癌预后的相关性。方法: 用免疫组化方法检测62例临床乳腺癌标本中LRP16、ER、PR和E-cadherin的表达。结果: LRP16、ER、PR和E-cadherin在临床乳腺癌标本中表达的阳性率分别为56.5%、56.5%、48.4%、40.3%。LRP16在临床乳腺癌中的表达与肿瘤大小、腋窝淋巴结转移、临床分期、ER表达呈正相关,与E-cadherin表达呈负相关(P<0.05)。E-cadherin在临床乳腺癌标本中的表达与腋窝淋巴结转移、临床分期呈明显负相关(P<0.05)。结论: LRP16与乳腺癌生物学行为密切相关,可以作为乳腺恶性程度评判的新指标。

Abstract: Objective: To investigate the expression of LRP16 gene in breast carcinoma and its relation with prognosis of breast carcinoma. Methods: Immunohistochemical method was employed to detect the expression of LRP16,ER,PR and E-cadherin in 62 cases of breast carcinoma. Results: The positive rate of LRP16,ER,PR and E-cadherin in breast carcinoma was 56.5%,56.5%,48.4%,and 40.3%,respectively.LRP16 was positively correlatated with the size of tumor,axillary node metastasis,clinical classification,ER expression and negatively correlated with the expression of E-cadherin（P＜0.05）.E-cadherin was negatively related with of axillary node metastasis,clinical classification（P＜0.05）. Conclusion: Expression of LRP16 is closely related with the malignant biological behavior of breast carcinoma and can be used as a new marker for evaluation of tumor malignancy.

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