Abstract: Objective To study the intra-operative nursing for children with congenital heart disease（CHD） during interventional closure under general anesthesia. Methods Of the 30 children with CHD（13 males,17 females） at the age of 1-8 years（2±3.2 years） enrolled in this study,12 underwent ventricular septal defect closure,7 atrial septal defect closure,8 patent ductus arteriosus closure,and 3 pulmonary valve stenosis valvoplasty under the guidance of X-ray and UCG.The patients were closely monitored by ECG during operation in order to prevent complications. Results The operation was a 100% success with no complications occurred. Conclusion Careful intra-operative care,skilled collaboration and close monitoring play important role in the success of operation for children with CHD under general anesthesia.