Abstract: Objective To explore the relation between chronic stress and serum cortisol,epinephrine and norepinephrine levels. Methods SCL-90,TCSQ and PSSS were used to assess the stress in 847 soldiers stationed in the gobi.Serum cortisol,epinephrine and norepinephrine levels were measured.U-test,linear regression and multiple stepwise regression were used to analyze the data. Results The SCL-90 score and serum cortisol,epinephrine and norepinephrine levels were significantly higher in soldiers stationed in the gobi than in normal Chinese（P＜0.01）.The SCL-90 score was correlated with the serum cortisol,epinephrine and norepinephrine levels（P＜0.05）.Multiple stepwise regression confirmed that SCL-90 and norepinephrine were the influencing factors for epinephrine. Conclusion Chronic stress may be related to increased serum epinephrine level.