Abstract: Objective To compare the safety of structured triglyceride（STG） and physically mixed medium chain triglyceride/long chain triglyceride（MCT/LCT） used in treatment of hyperbilirubinemia patients. Methods Fifty hyperbilirubinemia patients admitted to our hospital from 2008 to 2009 with a serum total bilirubin of 200-400μmol/L on the postoperative day were divided into STG group（n=25） and MCT/LCT group（n=5）.Their parenteral STB and MCT/LCT nutrition in patients for≥5 days was retrospectively analyzed. Results The ALT,AST,AKP,γ-GT and bilirubin levels were significantly lower in the two groups 1 and 5 days after the STG and MCT/LCT were used than before they were used（P＜0.05）.However,no significant difference was found in triglyceride between the two groups（P＞0.05）. Conclusion The effects of STG and MCT/LCT are not significantly different on the liver function of hyperbilirubinemic patients.