传染性非典型肺炎患者血清酶活性及CRP、Fn的变化

The studies on the changes of serum enzymes,CRP and Fn in SARS patients

摘要: 目的：探讨SARS患者血清中CRP、Fn和反映组织细胞损伤的血清酶活性变化规律。方法：观察SARS患者急性发病期和康复期血液中各项指标的变化，血清LDH、CK、ALT和AST活性采用ROCHE诊断公司速率法试剂盒在日立7600全自动生化分析仪测定，血清CRP和Fn测定采用ELISA方法。结果：急性期患者CRP明显升高，同时伴随血清LDH、CK、ALT和AST活性的部分升高，至恢复期CRP明显降低，血清ALT和LDH活性进一步升高，而AST和CK基本恢复正常；Fn在急性期明显降低，康复期恢复正常水平。结论：SARS患者康复期血清反映细胞膜损伤的酶活性进一步升高，提示组织细胞损伤持续存在。

Abstract: Objective: to evaluate the changes of serum CRP，Fn and enzymes in acute phase and convalescence of SARS patients. Methods: Serum CRP and Fn have been measured by ELISA method and LDH，CK，AST，ALT have been measured by using Hitachi 7600 automatic analyzer.Results: The increased serum CRP，LDH，CK，AST，ALT and decreased serum Fn have been found in acute phase patients.CRP and Fn will be going to normal in convalescence patients，but serum ALT and LDH activity increased constantly，whereas AST and CK were approaching to normal.Conclusion: The increased serum enzyme activity indicated that there were constantly cell injury even in the onset of illness of SARS.