慢性病毒性肝炎病理改变与肝纤维化关系研究

Correlation between liver pathological changes and fibrosis in chronic viral hepatitis

摘要: 目的：研究慢性病毒性肝炎病理改变与肝纤维化关系。方法：对37例慢性病毒性肝炎（CVH）肝组织进行病理学检查，并检测其血清Ⅲ型前胶原肽（PⅢP）、层粘蛋白（LN）、Ⅳ型胶原（ⅣC）、透明质酸（HA）等。结果：汇管区炎细胞浸润明显患者血清LN、ⅣC、HA明显升高。PⅢP在碎屑样坏死时明显升高。小叶内炎细胞浸润明显及有桥接样坏死者，血清LN、ⅣC、HA均明显升高。淤胆患者血清HA较无淤胆患者升高明显。同时伴随肝细胞再生者血清LN亦明显升高。结论：CVH的炎症、坏死、肝细胞再生以及淤胆等病理过程均与肝纤维化的形成有关

Abstract: Objective: To study the correlation between liver pathological changes and the serum markers of fibrosis in chronic viral hepatitis （CVH）.Methods: Pathological changes of liver tissue from 37 cases with CVH were studied and serum precollagen Ⅲ pre peptide （PⅢP）,laminin （LN）, collagen type Ⅳ （ⅣC） and hyaluronic acid （HA） were detected by enzyme immunoassay.Results: The levels of serum LN, ⅣC and HA were closely correlated with the degree of inflamation and bridge necrosis in liver tissues （P＜0.05~0.01）. While serum PⅢP was closely correlated with the piecemeal necrosis （P＜0.05）. Conclusion: The pathological changes in liver tissues of CVH were correlated closely with liver fibrosis.