Abstract: Objective: To investigate the changes of maleic dialdehyde（MDA） levels and superoxide dismutase（SOD） activities in the lung tissues of rabbits with endotoxin-induced acute lung injury（ALI）,and study the protective mechanism of xuebijing. Methods: 24 male Japanese flap-eared white rabbits were randomly divided into 3 groups: control group（Group A）,endotoxin-induced ALI group（Group B） and xuebijing treatment group（Group C）.ALI models of the rabbits were replicated by intravascular ET injection（750μg/kg）,and xuebijing（1.8mL/kg weight）was intravascularly injected in xuebijing treatment group. Results: MDA levels in-Group B was significantly higher than in Group A（P＜0.01） and Group C（P＜0.05）,and there was no difference between Group A and Group C.SOD activities in Group B were lower than in Group A（P＜0.01） and Group C（P＜0.05）,and no difference was found between Group A and Group C. Conclusion: Xuebijing can significantly lower MDA levels and increase SOD activities in lung tissues.Xuebijing may have the effect of protecting rabbits with endotoxin-induced ALI.