Abstract: Objective To study the clinical characteristics of multiple myeloma with double clones and analyze its related laboratory diagnostic and therapeutic methods. Methods A case of multiple myeloma with double clones of IgG-κ and IgG-λ was reported and its related literature was reviewed. Results The myeloma protein ingredients were different between multiple myeloma with double clones and typical multiple myeloma.Immune fixation electrophoresis was of diagnostic value for multiple myeloma with double clones.The treatment outcome was usually a decreased or disappeared myeloma protein ingredient.The prognosis of patients was rather good. Conclusion Multiple myeloma with double clones is a rare plasma cell disorder,which is different from typical multiple myeloma in clinical manifestations,diagnosis,treatment and prognosis,and should thus be differentially diagnosed from typical multiple myeloma.