Abstract: The serum CEA in 559 random-selected donors was tested.The individuals subjected to examination consisted of 5 groups:（1）healthy subject group,（2）that with increase in SGPT,（3） that with positive HBsAG,（4）that with elevation of SGPT and HBsAG,and（5）smokers.The result demonstrated that CEA was markedly increased in groups（2）and（3）,with statistical significance（P＜0.05）.It may be considered,therefore,that the positive serum CEA may indicate the occurrence of hepatic disease.As to the possibility of trasmitting hepatitis by the use of blood from the healthy but CEA-positive donors,in the practice in our hospital so far we did not confront with this condition in 23 cases transfused with the blood from healthy but CEA-positive donors.Undoubtedly,this point still requires further investigation.