VEGF、NF-κB/p50在不同分型涎腺多形性腺瘤中的表达及意义

Expression of VEGF and NF-κB/p50 in different types of polymorphous adenoma of salivary gland and its significance

摘要: 目的检测VEGF、NF-κB/p50在细胞丰富型及基质丰富型涎腺多形性腺瘤中的表达并探讨其意义。方法采用SP免疫组化染色方法检测105例多形性腺瘤中VEGF、NF-κB/p50的表达。结果细胞丰富型中VEGF、NF-κB/p50的表达高于基质丰富型(P<0.05);且两型中VEGF、NF-κB/p50的表达均高于正常涎腺(P<0.05)。VEGF与NF-κB/p50的表达呈正相关。结论多形性腺瘤新生血管形成能力及细胞增殖活性随着瘤体中细胞成分的增多而逐渐升高,细胞丰富型多形性腺瘤较基质丰富型具有更易恶变的倾向。

Abstract: Objective To study the expression of VEGF and NF-κB/p50 in cell-rich and matrix-rich polymorphous adenomas of salivary gland and it significance.Methods Expressions of VEGF and NF-κB/p50 in 105 patients with polymorphous adenomas of salivary gland were detected with SP immunohistochemistry staining.Results The expression level of VEGF and NF-κB/p50 was higher in cell-rich and matrix-rich polymorphous adenomas than in normal salivary gland（P＜0.05）.The expression of VEGF was positively correlated with that of NF-κB/p50.Conclusion The ability of polymorphous adenomas to form blood vessels and proliferation of cells increase with the increased number of cells in the tumor.Cell-rich polymorphous adenomas are easier to become malignant than matrix-rich polymorphous adenomas.