Abstract: Objective To study the efficacy and safety of caspofungin on lung fungal infection in patients with malignant hemopathy after chemotherapy or during stem cell transplantation. Methods Efficiency and adverse effects of caspofungin on lung fungal infection in patients with malignant hemopathy were retrospectively analyzed. Results The total effective rate of caspofungin for lung fungal infection was 80%（16/20）.Among the 20 cases,completely recovery was achieved in 1,excellent improvement in 13,improvement in 2,and response to caspofungin treatment in 4,respectively.The main adverse effects of caspofungin were elevated hypopotassaemia（13/20）,hypocalcemia（11/20）,hypoproteinemia（9/20）,transaminase,urea,bilirubin,ALP,and r-GT. Conclusion Caspofungin is very effective against lung fungal infection in patients with maliant hemopathy after chemotherapy or during stem cell transplantation with tolerable side-effects.