Abstract: Objective: The wound and eschar not only lead to the loss of large amount of body fluid but also play pivotal roles in the production of various toxins and inflammatory mediators. It is one of the most important stimulator of postburn hypermetabolism and MSOF. Methods: Experiences have been accumulated clinically in recent years which showed that it was both safe and beneficial for the burned wound to be excised and covered with cryopreserved allograft as soon as possible. Results: 63 cases of major burns are summed up in which the extensive burned wound excision in the acute shock stage and the coverage of excised burn wound with cryopreserved allograft skin were performed in this article.Conclusion: (1) The survival of major burn patients can be increased by extensive wound excision and the coverage of excised wound with autologous microskin and large sheet of allograft skin. (2) the allograft skin with high viability can ensure the performance of extensive wound excision. (3) with the summary of clinical effects of our data, several essential treatments in the excision are recommended: excising eschar and wound entirely, utilizing cryopreserved allograft skin with high viability, stanching bleeding perfectly, suturing and fixing firmly, binding up dressing suitably.