Abstract: This article reports an elderly female patient with acute cholangitis who had high fever, jaundice, and the comorbidities of space-occupying lesions in the pancreas, pulmonary infection, pleural effusion, urinary tract infection, coronary heart disease, and Parkinson’s disease, which led to the difficulties in diagnosis and treatment and high risks after surgery. After multidisciplinary discussions, the experts decided to conduct minimally invasive endoscopic retrograde cholangiopancreatography to avoid the risk of surgery and formulated rational diagnostic and therapeutic protocol and personalized anesthetic regimen for the patient. The patient was successfully discharged after surgery. Multidisciplinary cooperation provides anesthesiologists with suggestions for evaluating organ function and selecting surgical anesthesia and can effectively help anesthesia management, reduce perioperative risks, and better maintain the functional status of patients after surgery.