Abstract: Objective: To investigate the changes of corneal surface regularity and tear film after laser in situ keratomileusis （LASIK). Methods: Three hundred and ninety eight myopic eyes that underwent LASIK were oberserved, fluorescein staining（FL), tear break-up time（BUT), corneal topography was examined preoperatively and 1 day, 1 week, 2 week, 1 month, 3 month, 6 month, 1 year postoperatively. Results: The tear break-up time of whom wear contact lens was shorter than of those didn’t wear.The re were obvious decreases in BUT in 6 month postoperatively （P＜0.05), but surface regularity index（SRI), surface asymmetry index（SAI) were obvious increased in 1 year postoperatively.Conclusion: LASIK does have some effects on tear film, the surface irregularity of corneal maybe the cause of dry eye after LASIK.