HLA-B27与强直性脊柱炎临床及免疫学变化的关系

The link between HLA-B27 and clinical features and immunologic changes in ankylosing spondylitis

摘要: 研究了67例强直性脊柱炎(AS)患者的临床特点及免疫学变化与HLA-B27的关系。结果表明,HLA-B27阳性AS患者的发病年龄较HLA-B27阴性者平均早5年(P<0.05);HLA-B27阳性的AS患者中17.2%并发虹膜睫状体炎或急性结膜炎;血清IgG、IgA、IgM及Υ-球蛋白水平在HLA-B27阳性患者明显增高。提示AS患者的发病、眼部损害及体液免疫反应增强均与HLA-B27密切相关。

Abstract: The relationship between HLA-B27 and clinical features and immunologic changes was studied in 67 cases of ankylosing spondylitis （AS）. The results showed that the onset was 5 years earlier in HLA-B27 positive than that in HLA-B27 negative AS（P＜0.05）; iridocyclitis and acute conjunctivitis were noticed in 17.2% of HLA-B27 positive patients with AS; serum level of IgG, IgA, IgM and globulin was obviously eleevated in HLA-B27 positive AS. It is suggested that the disease onset, eye involvement and enhanced humoral immune responses in AS are closely related to HLA-B27.