几种珊瑚植入大鼠颅骨缺损的比较研究

Compare of several coral as bone graft substitute implanting mice cranial defects

摘要: 目的: 评价不同珊瑚的生物学性能。方法: 将致密澄黄滨珊瑚、疏松澄黄演珊瑚、普哥滨珊瑚、鸡冠蔷薇珊瑚四种珊瑚分别植入大鼠标准颅骨缺损区,分别于4周、8和12周时行大体观察、X线检查、及组织学检查。结果: 珊瑚的生物性能与其形态结构密切相关,致密澄黄滨珊瑚具有吸收慢、生物相容性好的优点,明显优于其他几种珊瑚。结论: 致密澄黄滨珊瑚有可能成为临床修复骨缺损的有效材料。

Abstract: Objective: This study was attempted to evaluate several coral biologic ability.Methods: Loose Porites lutea, compact Porites lutea, Porites pukonsis and Montipora sp. Cf. M implanted mice cranial critical size defects, The animals were sacrificed at 4,8,12 weeks respectively after operation and biologic ability was evaluated by histomorphometry, radiography and histology.Results: The degradate rate of compact Porites lutea was lower than other kinds of coral, and compact Porites lutea had good biocompatibility. Conclusion: compact Porites lutea will be a hopeful bone substitute to be used in repairing bone defect.