氨基酸清除率在肝脏功能储备测定的意义
An evaluation of clearance rate of aminoacids test for estimation of hepatic functional reserve
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摘要: 本研究是比较手术前氨基酸清除率(CRAA),吲哚氰绿排泄(ICGR15),口服葡萄糖耐量试验(OGTT),血清胆红素(BIL),白蛋白(ALB),凝血酶原时间(PT)在(Ⅰ组)肝胆疾病(10例)和(Ⅱ组)非肝胆疾病(5例)的差别以及其与肝组织ATP含量的相关性。结果:Ⅰ组的ICGR15全部大于10%,而Ⅱ组全部小于10%;Ⅰ组的CRAA值明显低于Ⅱ组(P<0.01);在与肝组织ATP含量相关性上,ICGR15最高(r=0.8674),CRAA次之(r=0.7872)。而其他的检查结果与肝组织的相关性不显著(P>0.05)。因此,CRAA是一较灵敏的肝贮备功能的检查方法,有一定的临床应用价值。Abstract: The ICGR15 ,clearance rate of aminoacids (CRAA), oral glucose tolerance test (OGTT) and several roultine hepatic function tests (Bil, GPT, PT, ALB) were made before operation in 10 patients with hepatobiliary diseases (group I) and 5 non hepaobiliary patients (groupⅡ). All the results were made correlative analysis with liver tissue ATP levels. Results showed that all the group I patients with ICGR15 >10%,while in group Ⅱ, all ICGR15 <10%;CRAA in group I was markedly lower than that in group Ⅱ. The ATP level of hepatic tissue was most correlated with ICGR15 and CRAA. Therefore, CRAA is a valuable test for evaluation of hepatic functional reserve before hepatic surgery is undertaken.
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