肝门部胆管癌134例临床分析

Clinical analysis of 134 cases of hilar cholangiocarcinoma

  • 摘要: 目的: 研究分析134例肝门部胆管癌临床诊治及远期疗效,探讨生存率与手术方式的关系及如何提高早期诊断率。方法: 分析解放军总医院肝胆外科1999年1月至2002年7月收治的肝门部胆管癌134例。结果: 手术组116例,其中根治性切除4 8例,姑息性切除21例,胆道引流4 7例;非手术组18例。总手术率86.6%(116/134),根治性切除率4 1.2%(4 8/116)。根治性切除组1,2,3年生存率分别为75.0%、4 5.8%、25.0%,姑息性切除组为50%、16.7%、0,两组之间的生存率比较有显著性差异(P<0.05);胆道引流组为25%、10%、0;非手术组平均存活5.7个月,无一例超过1年。结论: 肝门部胆管癌的治疗以手术为主,个体化和实用性的根治性切除术才能获得最佳疗效。对无黄疸性慢性肝病及胃肠道症状者定期体检及必要的影象学检查,是早期发现肝胆管癌的积极手段,赢得高生存率

     

    Abstract: Objective: To strive to standardize the radical resection of hilar cholangiocarinoma,and have better curative effects as well as better survivals. Methods: A retrospective analysis was performed in 134 patients from 1999 to 2002,of whom 48 cases had received radical resection of hilar cholangiocarcinoma. Results: Of the 134 patients,69 under resection (radical resection in 48;palliative in 21),47 subjected to internal or external drainage and 18 only laparotomy. The total excision rate and the radical resection rate was 86.6%(116/134)and 41.2%(48/116), the survival of the radical resection was 88.6%(39/44). The 1,2,3-year survival rate was 75.0%、45.8%、25.0% in radical resection group,and 50%、16.7%、0 in palliative resection group respectively,there is a remarkable difference between them. Whereas in unresectional internal and external drainage group,the 1,2,3-year survival rate was 25%、 10%、 0,All the patients with only laparotomy died within one year. Conclusion: The main treatment of hilar cholangiocarinoma is operation,and radical resection plays an important role for curative effect and long term survival rate in patients with H-CC.

     

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