Abstract: Objective: To evaluate the clinical effect of nonperforating trabecular surgery （NPTS） with reticulated sodium hyaluronic acid implant for treatment of primary open-angle glaucoma （POAG）. Methods: Sixteen eyes of 13 patients with advanced POAG underwent NPTS with reticulated sodium hyaluronic acid implant. Postoperatively, vision acuity, inflammation reaction, filtering bleb and intraocular pressure （IOP） were analyzed. Results: Postoperatively, vision acuityunchanged in 11 eyes、enhanced in 1 eyes and decreased in 4 eyes, inflammation reaction absented in 14 eyes and temporary presented in 2 eyes only slightly flash point, filtering bleb presented in all cases, IOP decreased in 14 eyes from preoperative （3.19 ± 0.33）kPa to postoperative 1 day mean 1.18 ± 0.48kPa （t= 13.67, P＜ 0.001 ） and postoperative 1 week mean（1.47 ± 0.50）kPa （t= 11.33, P＜ 0.001 ）, postoperative IOP slightly raised to 3.00kPa only 2 eyes, but after local drug treatment IOP was normal. After follow-up 3 ～ 12 months last IOPof all cases were about 2.00kPa. Conclusions: The elevated IOP of POAG can be effectively reduced by NPTS with reticulated sodium hyaluronic acid implant, and that the postoperative complications were singularly.