新型补体抑制剂对同基因大鼠移植肾功能的长期影响

Complement inhibition by a novel membrane-targeted complement regulator improves long-term renal isograft function in the rat

摘要: 目的: 观察新型补体抑制剂APT0 70对同基因大鼠移植肾功能的长期影响。方法: 应用同基因大鼠肾脏移植模型,供肾移植前分别经观察药物APT0 70、对照药物APT898及肾脏灌注液灌注,测定术后42 0周移植肾功能及2 4h尿蛋白含量。结果: 肾移植术后42 0周,APT0 70灌注组移植肾功能明显好于对照组,2 4h尿蛋白含量明显低于对照组,P<0.0 1。结论: APT0 70作为一种可与肾脏组织结合的新型补体抑制剂,可改善同基因大鼠移植肾的长期功能。

Abstract: Objective: to observe the effects of a novel membrane targeted complememt regulator on long term renal function after rat kidney transplantation Methods: Donor kidneys were perfused with APT070,APT898,and Collins solution before isograft kidney transplantation Renal functions and 24 hour urine protein were measured 4~20.weeks after transplantation Results: Renal functions and 24 hour urine protein were significantly improved by perfusing donor kidney with APT070（P＜0.001） Conclusion: APT070,a novel membrane targeted complement regulator can improve long term renal isograft function