Abstract: Objective: To explore the application of combined chemotherapy with vinorelbine and cisplatin in treatment of stageⅢnon-small cell lung cancer（NSCLC） before operation. Methods: A retrospective study was made in 57 patients with stageⅢnon-small cell lung cancer admitted to our hospital from March 2006 to December 2007.The patients were divided into experimental group（n=21） and control group（n=36）.Patients in experimental group were diagnosed as NSCLC by pathology.After a systematical examination,they were diagnosed asⅢA andⅢB lung cancer.Patients in experimental group received two cycles of NVB+DDP chemotherapy before operation,while patients in control group underwent operation. Results: The patients in experimental group responded to chemotherapy.The negative effect was observed mainly in digestive and blood systems.The effective rate was 52.38%（11/21）.The resection rate was 95.24%（20/21） in experimental group and 86.11%（31/36） in control group. Conclusion: Combined chemotherapy with vinorelbine and cisplatin has a high total effective rate for stageⅢnon-small cell lung cancer with few adverse effects,and can improve the quality of patient life.