老年肝癌自发性破裂的早期表现与治疗

Early manifestation and treatment of ruptured hepatocellular carcinoma in the elderly

  • 摘要: 目的: 总结老年人肝癌破裂出血临床特点、诊断治疗经验。方法: 回顾分析8例(14例次)肝癌破裂出血发病临床症状、体征。结果: 8例占同期肝癌的11.4 2%(8/70),静态发病、腹痛即刻达高峰,转移性下腹疼痛,伴出汗、恶心、呕吐,大便频;腹腔积血;超声提示有腹腔积液。经导管动脉栓塞(TAE)出血即刻停止,经手术切除者存活2731d。结论: 老年肝癌患者突发腹痛、出汗、便频常是肝癌破裂出血的信号,超声发现新的腹腔积液、或原有积液增多,腹腔穿刺证实腹腔积血。一般治疗补充血容量稳定生命体征;TAE是首选治疗方法,以后择期手术。

     

    Abstract: Objective: To summarize clinical features, experience of diagnosis and treatment of rupture hepatocellular carcinoma(HCC). Methods: Eight patients with ruptured HCC who were surgically or conservatively treated were retrospectively analyzed in terms of clinical features, modality of treatment, survival time, and cause of death. Results: The patients were admitted to the hospital from 1987 to 2002, accouting for 11.42%(8/70) of all hospitalized patients with HCC in the same period. Out of them seven patients were male, one patient was female. Sudden epigastric or right hypochondriac pain which decrease gradually with sweat, nausea, vomiting, hypotension and diarrhea. Blood pressures were lower than 90/60 mmHg in 6 patients and 87.5%(7/8) have signs of peritonitis. Blood-stained ascites exists in all cases and abdominal paracentesis is positive in overall. Median survival time were 54 days(range, 5 h~2 731 days). One patient, who was treated by emergent transcatheter arterial embolization(TAE), is still alive and well now in 6 months. One patient, who surgical resection was performed after hemostasis, had a survival time as long as 2 731 days. Six patients died in the hospital. Rebleeding was found in 4 hospitalized patients and was treated with conservative measures, resulting in all deaths. Conclusion: Ruptured HCC should be suspected in any patient with acute epigastric pain. Abdominal paracentesis should be performed. BUS, CT is valuable in the diagnosis of ruptured HCC because it is non-invasive procedure. While TAE remains the best method to employ for hemostasis, it still has limitations. Hence, we should be mindful of other possible modalities for hemostasis and their outcomes.

     

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