Abstract: Objective: In order to improve the long term survival of renal allografts, a study of effects of immunosuppressants on apoptosis of renal was designed in this series. Methods: Eighty five cases of failed renal allografts were investigated histopathologically. 85 specimens from pretransplant biopsy were simultaneously observed as a control group. Results: Apoptosis phenomenon in all cases was found with morphologically characterized nuclear breakdown. The degree of apoptosis in triple therapy group was significantly slighter than that in double therapy group （P ＜0 05）. Conclusion: Triple therapy can protect tubular epithelium from apoptosis more effectively than double therapy.