传染性非典型肺炎患者体液免疫特征初步研究
An initial study on the characteristics of humoral immunity of patients with infectious atypical pneumonia
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摘要: 目的：探讨传染性非典型肺炎(severe acute respiratory syndrome，SARS)患者特异性体液免疫特征。方法：采用ELISA技术检测SARS患者血清中特异性IgG和IgM水平。结果：SARS患者住院期间血清特异性IgG水平持续升高，阳性检出率为77.3%；特异性IgM抗体水平住院3周内持续升高，第3周达到最高值，阳性检出率达60.0%，第4周则迅速下降。SARS患者血清IgM阳性出现时间早于IgG1周。结论：SARS患者血清中均存在特异性IgG抗体，而特异性IgM只存在70%～80%患者血清中。SARS特异性抗体产生的时间和变化特点相似于其它传染性疾病。Abstract: Objective: to investigate the characteristics of humoral immunity of patients with SARS.Methods: The levels of the specific IgG and IgM in the serum of patients with SARS were detected by ELISA.Results: The specific IgG in serum of patients with SARS increased continuously during hospitalization，The maximal rate of positive samples was 77.3%；The levels of specific IgM increased continuously in the first three weeks during in-hospital，then the maximum of IgM was found in the third week，the positive rate were 60%， and decreased quickly during the for th week.The occurrence of the specific positive IgM was earlier than that of IgG by one week.Conclution: There were specific IgG antibody in serum of all patients with SARS and the specific IgM were only found in serum of 70%～80% patients with SARS.The generation time and the basic characteristics of the specific antibody of patients with SARS were similar to that of other infectious diseases.
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