急性痘疮样苔藓样糠疹临床、病理及免疫组化分析

Clinical histopathological and ultrastructural manifestations of pityriasis lichenoides et varioliformis acuta

摘要: 目的: 探索急性痘疮样苔藓样糠疹(PLEVA)的病因,寻求有效治疗方法。方法: 对我院12年中11例PLEVA患者的临床表现、组织病理、免疫组化及超微结构进行回顾性分析。结果: ①本组临床表现为全身泛发出血性丘疹为主的多形性皮疹;②组织病理及超微结构:以淋巴细胞性血管炎,淋巴细胞、红细胞游入表皮为特征;③目前治疗以皮质类固醇激素、非甾体抗炎剂、环孢素较为有效。结论: 环孢素可能是治疗重症PLEVA的有效药物。

Abstract: Objective: In order to find a more effective treatment for pityriasis lichenoides et varioliformis acuta（（PLEVA））.Methods: The clinical,histopathological,Immunohistochemistry and ultrastructural manifestations of PLEVA were investigated through the 11 patients at our hospital within the past 12 years.Results: ①The diffused hemorrhagic papules with polymorphic lesions were manifestations in PLEVA.②Under the microscopy and electronmicroscopy,the lymphocytic vasculitis with lymphocytes and red blood cell migrating into epidermis were observed.③ As for corticosteroids,nonsteroid anti-inflammatory drugs and ciclosporin,ciclosporin is the most effective drug for serious PLEVA. Conclusions: vCiclosporin maybe an effective treatment for serious PLEVA.