防晒制剂皮肤安全性的实验研究

Experimental study on skin safety of sunscreens

摘要: 目的: 探讨同一系列不同SPF (sunprotectionfactor)防晒制剂对皮肤的安全性,筛选安全有效的防晒制剂配方。方法: 选用白化豚鼠背部去毛,分别涂抹SPF值为15、28、30⁺三种防晒制剂,以UV光源照射,波长为320～4 00nm,强度为(168± 2) mW/cm²。结果: 三种不同SPF防晒制品对实验动物皮肤各时相点反应积分为,SPF15组为0;SPF28组为1;SPF30⁺组为3。结论: 三种不同SPF值产品对皮肤的光毒性有一定差异,提示SPF值在28以内的防晒制剂皮肤安全性较好,SPF30⁺的防晒制剂对皮肤有一定光毒刺激反应。

Abstract: Objective: Aim To investigate the effects of Sunscreens with different Sun protection factor （SPF） on guinea pig Skin. Methods: 12 White guinea pigs （half males and females,weighing 350±8g ） were divided randomly into SPF15,28,and 30⁺ three group.The animals were shed and defend to bask over the back. Then the animal were ray radiation （168 ±2）mW/cm² with UV 320-400 nm. Results: In three sun-screening agent with different sun protection factor,skin reaction integral of group SPF 15 was 0,group SPF 28 was 1 and group SPF 30⁺ was 3. Conclusion: The results were suggested that there were a good safe in group SPF 15 and group SPF 28,there was handsome photosensitive reaction in group SPF 30⁺.