Abstract: Objective To study the role of K⁺ opener in arterial function remodeling of rats with renal hypertension（RH）. Methods Forty 6-weeks-old SD rats were randomly divided into group A（control group）,group B（2K1C group）,group C（pinacidil group）,and group D（pinacidil + glibenclamide group）,10 rats in each group.Three weeks after a renal hypertension model of rat was established with 2K1C,rats in groups C and D were given drugs by gastric lavage.Blood pressure of rats in different groups was then measured each week.The rats were killed after 6 weeks with their left femoral artery and abdominal aorta removed for in vitro arterial circle experiments.Effect of KCl,NE and NTG on blood pressure was observed. Results The blood pressure of rats in groups C and D began to increase one week after the model was established（P＜0.05）,and reached its peak three weeks after the model was established（P＜0.01）,with no significant change in heart rate.The blood pressure was lower in group C than in group D（P＜0.05） 6 weeks after drugs were given by gastric lavage.The effect of KCl and NE on systolic pressure was stronger while the effect of NTG on diastolic pressure was weaker in group B than in group A（P＜0.05）.The effect of KCl and NE on systolic pressure was weaker while the effect of NTG on diastolic pressure was stronger in group C than in group B（P＜0.05）. Conclusion K⁺ opener,pinacidil,can improve the arterial function in rats with renal hypertension,and may play a certain role in arterial function remolding of rats with renal hypertension.