Abstract: Objective: To determine the effect of aminophylline as an adenosine receptor antagonism on the victims of cardiac arrest refractory to epinephrine. Methods: 13 patients with cardiac arrest refractory to epinephrine received aminophylline （0.5~1.0 g,IV）. Cardic rhythms, blood prssure and respiration situation were recorded before and after intervention. Results: 10 cases had a return of spontaneous circulation and respiration （76.9%,10/13） after aminophylline injection. The survived rate of these patients in 6 h and 24 h was 61. 5% （8/13） and 46.1% （6/13） respectively. Only one patient resuscitated successfully and was perfectly conscious. Two cases resuscitated successfully, but their cerebral function was lost. Conclusion: Our results suggest the adenosine receptor antagonism, aminophylline, may have a rloe in the treatment of cardiac arrest refractory to epinephrine, and has some beneficial effect on the returning of organized cardiac electrical activity, spontaneons circulation and respiration.