Abstract: Objective: To study effects of preemptive analgesia with non-steroidal anti-inflammatory drugs（NSAIDs）.Methods: 66 adult patients（ASAⅠ-Ⅱ） scheduled to take gynecological laparoscopic surgery were randomly divided into three groups（each group 22）.Before induction of anesthesia,flurbiprofen axetil microsphere injection 50 mg was given IV in Group A,lornoxicam 8 mg was adiministered IV in Group B,and in Group C,equivalent dose of 0.9% NaCl was injected as control.The pain score with visual analogue scale（VAS）,incidence of adverse events were recorded at the emergence from anesthesia,0.5,1,2,8 and 24 h after emergence.Results: at each observed point during 8 h after emergence,the VAS of patients in group A were significantly lower than in group B or group C（P＜0.05）.The VAS of patients in group B were markedly less than in group C during 2 h after emergence（P＜0.05）.Furthermore,no significant difference was found for side effects in three groups.Conclusion: Before induction of anesthesia,the administration of flurbiprofen axetil microsphere injection or lornoxicam IV in patients undergoing gynecological laparoscopic surgery provide adequate preemptive analgesic effect,and flurbiprofen axetil microsphere may be a better choice.