减压后脑肿大早期颅内压和脑中线移位相关性的实验研究

Experimental study of the correlation between ICP and shift of cerebral midline in early stage of postdecompressive brain bulk enlargement

摘要: 目的：探讨减压后脑肿大早期颅内压（ICP）和脑中线移位的相关性。方法：应用生理监护仪对6只猫作减压后6h内颅内压连续监测，应用T1加权MRI（T1WI）对相同的6只猫作减压后2h、4h、6h颅脑影像动态观察。结果：减压后6h内颅内压快速增高；肿大的大脑半球向对侧移位逐渐加重。结论：减压后脑肿大早期（＜6h），颅内压和脑中线移位呈中度正相关（相关系数0.61），都能准确反映减压侧脑肿大的程度。

Abstract: Objective：To explor the correlatin between ICP and shift of cerebral midline in early stage of postdecompressive brain bulk enlargement.Methods：Used physical monitor，ICP was measured continuely in 6 cats within 6h after decompression.T₁WI was performed in the same 6 cats at the three time points （2h，4h or 6h after decompression） to examine the shift of cerebral midline.Results： ICP raised shortly and obviously after decompression.The swollen hemisphere shifted increasingly to the contralater.Conclusion： There was medium positive correlation （coefficient=0.61） between ICP and the midline shift in early stage （＜6h） of post decompressive brain bulk enlargement.Both of ICP and the midline shift could show definitely the swollen degree of the hemisphere in decompressive side.