Abstract: Objective: To improve early diagnosis and treatment of duodenal papilla tumor. Methods: 79 cases of duodenal papilla tumor were confirmed by operation and pathology from 1992 to 2002, and their clinical data were analyzed retrospectively. Results: There were 71 cases of duodenal papilla carcinoma, 5 cases of duodenal adenoma and 3 cases of atypical hyperplasia in these series.The first clinical manifestation were painless jaundice （61 cases）, dull pain and distention in upper abdomen（14 cases） and hemorrhage of upper digestive tract（4 cases）.The accuracy of ERCP, Fiberoptic duodenoendoscopy, MRCP.BUS and CT were 100%, 92.4%, 86.7%, 84.8% and 72.2% respectively.46 cases underwent pancreatoduodenectomy, 30 cases received local resection, the remaining 3 cases were treated by palliative surgery. Conclusion: Fiberoptic duodenoendoscopy and ERCP are major methods for diagnosis of duodenal papilla tumor.It is essential to diagnose early and select rationale operation to improve the results of surgical treatment.