Abstract: Objective: To observe the influence of Siqikang（bacillus calmate guerin-polysaccharide nucleinic acid: BCG-PSN） combined specific desensitization（SIT） upon serum IgE and IL-4 of the bronchial asthmatic patients during the remission stage.Methods: 90 cases of the bronchial asthmatic patients during the remission stage were selected and randomly divided into three groups,to who respectively was given the treatment of Siqikang（BCG-PSN）,SIT and Siqikang（BCG-PSN） combined SIT（conbined treatment group）.The changes in serum IgE and IL-4 were compared between these 3 groups.Results: After 36 d treatment,IL-4 level of the patients in the combined treatment group started to decrease,and IL-4 level was significantly lower in 108 d（6.50±8.30）ng·L^-1,there was a significant difference between the combined group and the other two groups（P＜0.05）,and there was a decrease in total serum IgE（261±329）mg·L^-1.Conclusion: The combined treatment of Siqikang（BCG-PSN） and SIT can not only effectively reduce the the inflammatory factors in body of bronchial asthmatic patients during the remission stage,but also have faster effectiveness.