Abstract: Objective: To evaluate the significance of comprehensive treatment of severe pulmonary infection in patients after kidney transplantation,and investigate the prognosis of severe pulmonary infection in patients after kidney transplantation. Methods: The clinical data of 45 patients with severe pulmonary infection following kidney transplantation were analyzed retrospectively. Results: Among 45 patients,32 patients were cured and 13 patients died.6 patients gave up therapies due to high expenses.The mortality rate of patients who were complicated with cytomegalovirus infection,bacterial infection,acute respiratory distress syndrome（ADRS） significantly increased.Duration of pulmonary infection was proportional to mortality.Sex and type of immune depressant were not significantly correlated with mortality. Conclusion: De-escalation therapy with high potency drugs has proved to be successful in treating severe pulmonary infection in patients after kidney transplantation.Immunosuppressant should be reduced or withdrawn and gamma globulin be added when excess immunologic suppression occurs.