胰岛素泵及常规胰岛素治疗早期糖尿病肾病的对比研究

Study on comparison of insulin pump and regular insulin in the treatment of early diabetic nephropathy

摘要: 目的:观察胰岛素泵治疗(CSII)与常规胰岛素治疗(MSII)对早期糖尿病肾病(DN)患者的疗效差异。方法:分别用胰岛素泵治疗(CSⅡ)和常规胰岛素治疗(MSⅡ)方法对40例和46例同期住院的早期糖尿病肾病患者进行了治疗。结果:CSII治疗组和MSII治疗组糖尿病肾病患者治疗后尿微量白蛋白排泄率(UAER)均明显下降。β₂微球蛋白(β₂M)也下降;但CSII组糖尿病肾病患者较MSII组下降更为明显。结论:胰岛素治疗能降低早期糖尿病肾病患者尿微量白蛋白及β₂微球蛋白,而胰岛素泵治疗效果更理想。

Abstract: Objective:To compare the different effect between continuous subcutaneous insulin injection（CSII） and multiple subcutaneous insulin injection（MSII） on diabetic nephropathy.Methods: 40 cases of early diabetic nephropathy with CSII and 46 cases with MSII were treated in the same period of time.Results: the urinary albumin excretion rate（UAER） of both CSII and MSII group were significantly decreased after treatment.and the β-2 microglobulin（β-2M） were decreased as well.but the UAER and β-2M in CSII group had a more remarkable decrease than that in MSII group.Conclusion: Insulin injection could decrease the urine microalbumine and β-2M of early diabetic nephropathy.and CSII could get a more effective treatment.