实验性过敏性脑脊髓炎的血脑屏障改变

Changes of blood-brain barrier in guinea pigs with experimental allergic encephalomyelitis

摘要: 目的：探索血脑屏障改变在中枢神经系统炎性脱髓鞘病中的作用。方法：采用免疫组化等方法对髓鞘碱性蛋白诱发的实验性过敏性脑脊髓炎病程中的血脑屏障改变进行了研究。结果：在临床症状出现前3d，血脑屏障的通透性已出现明显改变。结论：血脑屏障的通透性的改变，在中枢神经系统炎性脱髓鞘病的发病中起重要作用

Abstract: Objective:To explore the changes of blood-brain barrier（BBB） in the pathogenesis of CNS demyelinating diseases.Methods:The blood-brain barrier in guinea pigs with experimental allergic encephalomyelitis （EAE） was examined by using anti-guinea pig IgG immunohistochemical method and HRP injection into the common carotid artery.Results:The disruption and increased permiability of BBB occurred in EAE three days before the appearance of clinical symptoms.Conclusion:The result indicate that disruption of BBB occurred in CNS may play an important role in the pathogenesis of EAE.