Abstract: Radionuclide salivary scintigraphy was carried out on 49 cases of xerostomia usingTc-99m-O 4.Judged by tracer uptake,distribution and clearance of parotid glands,and other im-aging characteristics,the scintigram were graded into four groups:normal（-）5,slightly abnor-mal（+）19,mild（） and severe abnormal（）,20 and 5 cases respectively, In most cases,no correlation was observed among age,sex,duration of illness,lab findings and scintigraphicappearence,but significant relationships were revealed between scintigraphy and γ-globin;Longer history of disease was demonstrated in patients in（）group.Good theraputic responeswere observed in most cases,with 2 cured cases being in（-）group,while 2 noneffective casesbeing（）.On the whole,the true-positive rate of salivary scintigraphy in diagnosing xerostomiais 90%,and specificity is 91.6%.