慢性淋巴细胞白血病的临床免疫分型和细胞周期分析

Clinical, immunophenotypic and cell cyclic analysis of chronic lymphocytic leukemia（CLL）

摘要: 15例慢性淋巴细胞白血病（CLL）用一组单克隆抗体作免疫分型。13例为B-CLL,主要表型为CD20⁺、HLA-Dr⁺、SmIg⁺、CD5/Em⁺。2例T-CLL,1例Ts-CLL,1例为Dr⁺的T-CLL。CLL骨髓中Go+G₁期细胞为91.1±2.3%（对照76.0±5.1%）,S+G2M期细胞为8.9±2.3%（对照23.9±5.1%）,外周血中各种周期的细胞比例与骨髓无显著差别。3例CLL在病程中发生幼淋样变。对CLL的临床过程,细胞化学,和免疫学改变作了分析。

Abstract: 15 cases of CLL were immunophenotyped with a panel of monoclonal antibodies. 13 cases BCLL, which was characterized by CD₂0⁺, HLA-Dr⁺, Smlg⁺, CDs⁺and Em⁺. 2 cases were T-CLL, one with Ts phenotype and the other with Dr⁺T-CLL. The ratio of G0+G1 cells in bone marrow of CLL was 91.1±2.3%（76.0±5.1% in controls）, while S+G₂M cells was 8.9±2.3% （23.9± 5.1%in controls）. The ratios of various cyclic cells were similar in bone marrow and in peripheral blood. Prolymphocytoid transformation developed in late stage of 3 CLL patients. The clinical course, cytochemistry and immunologic changes in CLL are also analysed in this paper.