Abstract: Objective: To investigate the influence of different contents of purines in diets on serum uric acid and its excretion in hyperuricemic elderly men.Methods: Ten hyperlipidemic elderly men mean age（74.4±7.84） years old consumed high-purine（＜800 mg/d） and low-purine diets（＜250 mg/d） for three days.At onset and after purine load,the samples of fasting blood and 24h urine samples were collected for determination of serum biochemical variables,and 24h uric acid urinary excretion,24h urinary creatinine,Urinary uric acid excretion was calculated.Results: The levels of serum uric acid were decreased and increased respectively after low and high purine diets.The patients with hyperuricemia showed 24h uric acid urinary excretion,urinary uric acid to creatinine ratio,fractional excretion of uric acid and excretion of uric acid per volume of glomerular filtration were increased significantly both at low and high purine diets.The uric acid clearance and fractional excretion of uric acid were significantly higher in low purine diets than in high purine diets.Conclusion: Low purine diets with purine ＜250 mg/d significantly decrease serum uric acid level of patients with hyperuricemia and elevate renal excretion of uric acid.The serum uric acid level is significantly increased by high purine content diets.The dietary restriction of purines,protein and fat intake is effective to control serum uric acid level and protect renal function.