Abstract: Objective To observe the effect of Fufang Tianpu tablet extraction on hemorheological changes in rats after +10Gz exposure. Methods Sixty male SD rats were randomly divided into control group,+10Gz group,and low,medium,high dose Fufang Tianpu tablet extraction groups.The rats were exposed to +10Gz for 5min.Anti-coagulated blood was collected from rats after +10Gz exposure and hemorheological parameters were detected. Results The low,medium and high shear blood viscosity was obviously higher in +10Gz group than in control group（P＜0.05）,and significantly lower in +10Gz group than in low,medium and high dose Fufang Tianpu tablet extraction groups（P＜0.05）.The hematocrit was significantly higher in +10Gz group than in control group（P＜0.01） and significantly lower in +10Gz group than in low,medium and high dose Fufang Tianpu tablet extraction groups（P＜0.01）.The middle and high reduction shear blood viscosity was significantly lower in low and medium dose Fufang Tianpu tablet extraction groups than in +10Gz group（P＜0.01） and similar with that in control group. Conclusion Fufang Tianpu tablet extraction can protect rats against changes in hemorheology after exposure to +10Gz.