新生儿重组酵母乙肝疫苗接种免疫的研究

闫炜炜; 李润芳; 王苏玲; 雷云凤

新生儿重组酵母乙肝疫苗接种免疫的研究

Study on recombinant hepatitis B vaccine immunogenicity in infant

摘要

摘要: 目的: 探讨重组酵母乙肝疫苗新生儿接种后抗体应答持续时间,强化复种的必要性。方法: 常规对新生儿0d (出生后当天)、1月、6月接种重组酵母乙肝疫苗后检测抗体应答情况,再随机分两组,一组为强化组,一组为常规组,并随访其5年的抗体应答情况。结果: 新生儿常规接种法,于12个月后有一明显抗体应答下降期(0d、1月、6月、12月),强化组乙肝表面抗体形成率高,持续时间均高于常规接种法。结论: 新生儿乙肝疫苗0d、1月、6月、12月接种法有较好的远期保护效果,对现有的0d、1月、6月新生儿乙肝疫苗常规接种法,有强化接种的必要。

Abstract: Objective: To investigate the antibody response to hepatitis B vaccination and the necessity of reinforcement of recombinant hepatitis B vaccine （RHBV） at 12 month. Methods: Infants were divided into two groups at random. RHBV was administered on 0 day,1 month,6 months in routine-group, and RHBV was administered on 0 day,1 month,6 months,12 months in reinforce-group. Positive rate of HbsAb titers and duration of HbsAB were measured in 12,18,30,60 months. Results: The positive rate of HbsAb of infants was lower than the reinforce-group. There is a significant difference in the duration of HbsAb of infants that the reinforce-group is much longer than routine-group（P＜0005）. Conclusions: In many individuals, RHBV promote a full, longer-lasting antibody response after reinforcing in 12 months.

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