Abstract: Objective To study the clinical diagnosis,treatment and prognosis of patients with meningeal metastasis of lung cancer. Methods Clinical diagnosis,treatment and prognosis of 10 patients with meningeal metastasis of lung cancer admitted to our hospital from 2006 to 2011 were retrospectively analyzed. Results Primary lung cancer in 10 cases was confirmed by pathology and meningeal metastasis of lung cancer was diagnosed by MRI.Among these patients,cancer cells were found in cerebrospinal fluid（CSF） of 2 patients,5 were treated with targeted drugs alone,2 were treated with targeted drugs plus whole cerebral radiotherapy,1 was treated with intrathecal chemotherapy,intrathecal radiotherapy and targeted drugs,1 was treated with intrathecal chemotherapy,whole cerebral radiotherapy and targeted drugs.The total survival time of patients was 4weeks-24 months and the median survival time of patients was 8 months. Conclusion Meningeal metastasis is one of the most critical complications of lung cancer with a rather high mortality.Its early diagnosis and treatment can prolong survival time of such patients and improve their prognosis.