老年胃癌患者预后多因素分析

Significant prognostic factors by multivariate analysis in elder patients with gastric cancer

  • 摘要: 目的: 研究影响老年胃癌预后的独立因素。方法: 采用单因素,Kaplan meier生存曲线及COX多因素回归分析了92例老年胃癌患者临床病理因素及治疗措施对预后的影响。结果: 单因素分析表明,老年胃癌预后与血小板计数、体重、肿瘤大小、浸润深度、淋巴结转移及TNM分期有关(P<0.05),COX多因素回归分析表明TNM分期、淋巴结转移和血小板增多是影响老年胃癌预后的独立因素,TNM分期Ⅰ期、无淋巴结转移和血小板≤ 30×1012/L的5年生存率分别为91.2%、92.3%、86.7%,而Ⅳ期、淋巴结转移和血小板>30× 1012/L的5年生存率分别为41.7%、4 4.4 4%、50%(P<0.01),根治性手术仍是影响胃癌预后的重要因素。结论: TNM分期、淋巴结转移和血小板增多是影响老年胃癌预后的独立因素。

     

    Abstract: Objective: The aim of this study was to indentify and measure the prognostic factors in elder patients with gastric cancer. Methods: Univariate and multivariate analyses of the prognostic value of Various pathological and treatment variables in 92gastric cancer. Survival was compared by using the log-rank test on the kaplan-meier life table. Results: On univariate analysis,significant prognostic factors were plt,Weight,size of tumour,depth of invasion,lymph node metastasis,histologic differentiation and TNM stage(P<0.05),On multivariate analysis,independent prognostic factors were TNM stage,lymph node metastasis and thrombocytosis(P<0.01),The radical gastrectomies is recommended to lengthen survival in elder patients with gastric cancer. Conclusion: TNM stage,lymph node metastasis and thrombocytosis are independent prognostic indicator of survival in elder patients with gastric cancer.

     

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