Abstract: Objective To study the self-care methods of oral infection in patients with systemic lupus erythematosus（SLE）. Methods Oral infection in 87 SLE patients was analyzed.Effect of nursing intervention on oral infection in SLE patients was observed. Results SLE patients were susceptible to oral infection due to immunological hypofunction during treatment.The painful feeling resulted from oral infection would severely affect their life quality.Oral infection was related with low-protein level,neutropenia and inappropriate gargling（P＜0.05）.Alternative gargling with 1∶5 000 liquor furacilinum and 1∶10 000 liquor nystatin could relieve oral pain and control oral infection. Conclusion SLE patients should strengthen their self-care conception and gargle with 1∶5 000 liquor furacilinum and 1∶10 000 liquor nystatin in turn to prevent oral infection.