Abstract: Objective To study the effect of coronary artery bypass grafting（CABG） on coronary heart disease and hypothyroidism and the management strategies during pre-operation. Methods Clinic data about 11 patients who underwent CABG for coronary heart disease and hypothyroidism from January 2006 to September 2009 were retrospectively analyzed. Results The number of bypassed blood vessels was 2-4（2.96±0.51）.The stay time in ICU and the time of tracheal intubation were 50.2±11.6h and 14.5± 6.9h,respectively.Two patients underwent a second tracheal intubation due to low cardiac output.The patients were followed up for an average time of 24.5±16.7 months with a 100% survival rate. Conclusion CABG is a rather good procedure for coronary heart disease accompanying hypothyroidism.Early and appropriate thyoid replacement therapy can prevent the complications and risk of CABG.