Abstract: Objective To study the management strategy of thrombosis accompanying cerebral hemorrhage in patients with acute coronary syndrome（ACS）. Methods Clinical data about 1 patient with ACS accompanying cerebral hemorrhage and sub-acute stent thrombosis following percutaneous coronary intervention（PCI） were retrospectively analyzed with related literature reviewed. Results The ACS patient was a 76-year old male.Coronary angiography showed 3 lesions in coronary artery with a stenosis ＞50%.Cerebral hemorrhage occurred following PCI with dual anti-platelet and anti-thrombin agents.The patient underwent emergency PCI due to sub-acute stent thrombosis after withdrawal of anti-thrombotic agents and he was discharged from hospital 37 days after active treatment of complications by adding antithrombotic agents and monitoring coagulation. Conclusion The key to the treatment of ACS is to balance the thrombosis and hemorrhagic risk.Assessment of risk and adjustment of treatment pan can prevent and reduce the incidence of complications.