Abstract: Objective To study the clinicopathological features of cosmetics mercury poisoning-related nephropathy and its treatment methods. Methods Clinicopathological features of a female patient with cosmetics mercury poisoning-related nephropathy admitted to Department of Nephrology,Chinese PLA General Hospital,in November 2010 and her response to antimercurialism were analyzed. Results The patient developed nephritic syndrome after using whiten cosmetics that contains mercury for half a year.Her blood pressure,renal function,and serum autoantibody were normal.Pathologic examination showed stage 1 membranous nephropathy.The patient did receive any immunosuppressive agent.After antimercurialism,her urinary protein gradually decreased and systemic symptoms improved. Conclusion Cosmetics mercury-related nephropathy is manifested as nephrotic syndrome（which was diagnosed as stageⅠmembranous nephropathy in this patient who had a rather good response to antimercurialism）.